Clindamycin + Metronidazole + Clotrimazole is a combination of three medicines: Clindamycin , Metronidazole , and Clotrimazole, which treats vaginal infections. Clindamycin is an antibiotic which stops bacterial growth by preventing synthesis of essential proteins required by bacteria to carry out vital functions. Metronidazole is also an antibiotic which kills other infectious microorganisms in addition to bacteria by damaging their DNA. Clotrimazole is an antifungal medicine which stops the growth of fungi by preventing them from forming their protective covering.