Simvastatin and ezetimibe are two lipid-lowering drugs that work together to lower cholesterol levels by: Ezetimibe: Prevents the absorption of cholesterol from the intestines Simvastatin: Reduces the amount of cholesterol produced by the liver When taken together, ezetimibe and simvastatin are more effective at lowering LDL-C than either drug alone. This is because they work independently to alter the balance of cholesterol in the body.