Prucalopride is used in the treatment of heartburn, indigestion, constipation and irritable bowel syndrome. It helps in relieving constipation that is long-lasting or keeps coming back. This medication is used to treat chronic constipation. It is used when other mediations used to treat constipation (such as laxatives) have not provided relief. Prucalopride works by improving how well your stomach and intestines move food through the bowels during digestion.