Bacitracin + Neomycin + Polymyxin B is a combination of three antibiotics: Bacitracin , Neomycin and Polymyxin B. These antibiotics work by killing the bacteria or stopping their growth on the skin. Together, they treat your skin infection effectively. Polymyxin B sulfate, bacitracin, and neomycin are antibiotics that work by stopping bacterial growth. Polymyxin B sulfate increases the permeability of bacterial cell membranes by interacting with the phospholipid components of the membrane.