Additional information
| Therapeutic Segment | Immunosuppressants |
|---|---|
| Dosage Form | Tablets |
| Specialities | Nephrologist, Orthopaedic, Surgeons |
As directed by physician
Azathioprine is an immunosuppressant that works by inhibiting DNA, RNA, and protein synthesis -
Metabolism : Azathioprine is metabolized into mercaptopurine (6-MP), which is then bioactivated to form TGNs, the major active metabolites.
Incorporation into DNA : TGNs are incorporated into DNA, which inhibits DNA replication and cell proliferation.
Reduced immune activity : Azathioprine reduces the activity of the body's immune system, preventing it from attacking transplanted organs or joints.
Azathioprine is used to treat a number of conditions, including kidney transplant rejection, severe rheumatoid arthritis, and inflammatory bowel disease.
