Glimepiride works by Stimulates the pancreas to release insulin, thereby helping to lower blood sugar levels. and metformin works by Reduces glucose production in the liver and improves insulin sensitivity in peripheral tissues, aiding in better glucose utilization. Glimepiride stimulates cells in the pancreas that produce insulin, which helps remove sugar from the blood. Metformin reduces sugar production by cells in the liver and delays sugar absorption from the intestines.