Ketoconazole + Zinc pyrithione kills the fungus that causes dandruff and other scalp infections and reduces the amount of yeast and bacteria on the scalp. Pyrithione zinc is commonly found as an active ingredient in OTC antidandruff topical treatments such as shampoos. It mediates its action by increasing the cellular levels of copper, and damaging iron-sulfur clusters of proteins essential for fungal metabolism and growth. Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections.