METOPROLOL+CHLORTHALIDONE is a combination of two medicines: Metoprolol and Chlorthalidone. Metoprolol is a beta-blocker and works by acting on epinephrine, a hormone that can increase heart rate and blood pressure. So, blocking the action of epinephrine can result in a decrease in heart rate and blood pressure. Chlorthalidone is a diuretic or water pill that acts by expelling excess water and salt from the body. It helps in decreasing fluid accumulation and swelling or edema.