Nimesulide works by blocking the enzyme involved in the production of certain chemical substances during inflammation, which are responsible for causing pain, redness, swelling, and fever in the body. Hence decreasing the fever, pain, and swelling caused after injuries. Nimesulide which belongs to the group of medicines called Non-steroidal anti-inflammatory drugs (NSAIDs). It is used to manage inflammatory conditions, including joint disorders such as rheumatoid arthritis, posttraumatic and postoperative painful conditions, and fever. Nimesulide is also used to manage acute pain in orthopaedic, ENT, dental, and mild to moderate pain of osteoarthritis and rheumatoid arthritis.