Additional information
| Dosage Form | Tablets |
|---|---|
| Specialities | Diabetologist, Neurologist, Orthopaedic, Physician, Psychiatrist, Surgeons |
| Packing | 1 x 10 (Alu-Alu) |
| Therapeutic Segment | Nerve Rejuvenator |
Pregabaline 75 mg SR Tablets is a prescription medicine used for the treatment of neuropathic pain. It decreases pain by modulating the calcium channel activity of the nerve cells.
Treatment of Neuropathic pain
Take this medicine in the dose and duration as advised by your doctor.
Although the mechanism of action has not been fully elucidated, studies involving structurally related drugs suggest that presynaptic binding of pregabalin to voltage-gated calcium channels is key to the antiseizure and antinociceptive effects observed in animal models.22
By binding presynaptically to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, pregabalin modulates the release of several excitatory neurotransmitters including glutamate, substance-P, norepinephrine, and calcitonin gene related peptide.6 In addition, pregabalin prevents the alpha2-delta subunit from being trafficked from the dorsal root ganglia to the spinal dorsal horn, which may also contribute to the mechanism of action.15
Although pregabalin is a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), it does not bind directly to GABA or benzodiazepine receptors.8
As directed by physician
