Additional information
| Therapeutic Segment | Antianginal |
|---|---|
| Dosage Form | Tablets |
| Specialities | Cardiologist, Chest Physician, Physician |
As directed by physician
Ranolazine, is a medication that works to reduce the symptoms of angina and improve exercise tolerance in patients with coronary heart disease. The mechanism of action of ranolazine is not fully understood, but it is known to work by -
Inhibiting late sodium channels: Ranolazine prevents the late phase of inward sodium channels in cardiac myocytes, which reduces the intracellular sodium concentration. This reduces the amount of calcium that enters the cell, which decreases ventricular wall tension and oxygen consumption.
Stabilizing the myocardial cell membrane: Ranolazine's inhibition of late sodium channels also stabilizes the myocardial cell membrane, which may contribute to its anti-arrhythmic effect.
Inhibiting fatty acid oxidation: Ranolazine inhibits fatty acid oxidation, which increases glucose oxidation, reduces lactic acid production, and improves heart function
