Placeholder

Vortioxetine 10 mg Tablets

Vortioxetine 10 mg
Antidepressants
1 x 10 (Blister)
10 x 10
SKU: 255 Categories: , , Tag:

Additional information

Dosage Form

Tablets

Specialities

Neurologist, Physician, Psychiatrist

Packing

1 x 10 (Blister)

Therapeutic Segment

Antidepressants

Depression
As directed by physician
Vortioxetine is a novel multimodal antidepressant that acts as a serotonin (5-HT)3, 5-HT7, and 5-HT1D receptor antagonist; 5-HT1B receptor partial agonist; 5-HT1A receptor agonist; and 5-HT transporter inhibitor in vitro. In preclinical and clinical studies vortioxetine demonstrates positive effects on cognitive dysfunction. Vortioxetine's effect on cognitive function likely involves the modulation of several neurotransmitter systems. Acute and chronic administration of vortioxetine resulted in changes in histamine concentrations in microdialysates collected from the rat prefrontal cortex and ventral hippocampus. Based on these results and a literature review of the current understanding of the interaction between the histaminergic and serotonergic systems and the role of histamine on cognitive function, we hypothesize that vortioxetine through an activation of the orexinergic system stimulates the tuberomammilary nucleus and enhances histaminergic neurotransmission, which contributes to vortioxetine's positive effects on cognitive function.